|
KMID : 0360120120340050293
|
|
Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
2012 Volume.34 No. 5 p.293 ~ p.298
|
|
|
The Effects of Tetracycline-loaded Silk Fibroin Membrane on Guided Bone Regeneration in a Rabbit Calvarial Defect Model
|
|
Lee Sang-Woon
Park Yong-Tae
Kim Seong-Gon
Kweon Hae-Yong
Jo You-Young
Lee Heui-Sam
|
|
|
Abstract
|
|
|
Purpose: The aim of this study was to evaluate the bone regeneration ability of 1% tetracycline (TC)-loaded silk fibroin membrane (SFM), in a rabbit calvarial defect model.
Methods: Twenty New Zealand white rabbits were used for this study. Bilateral round defects were made on the rabbit parietal bone, using trephine bur with an 8 mm diameter. TC-loaded SFM or SFM was covered on the right parietal bone defect, and the left parietal bone defects were uncovered for the control. The animals were humanely sacrificed at 4 or 8 weeks postoperatively. A micro-computerized tomography (${\mu}$ 수식 이미지-CT) of each specimen was taken for analysis of bone regeneration. Hematoxylin and Eosin stain were done to observe histological findings.
Results: From the ${\mu}$ 수식 이미지-CT results, regenerated bone volume ($mm^3$ 수식 이미지) of 1% TC-loaded SFM, SFM, and control were $7.80{\pm}5.87$ 수식 이미지, $8.79{\pm}3.44$ 수식 이미지, and $10.61{\pm}5.3$ 수식 이미지 at 4 weeks postoperatively, respectively (P>0.05). Regenerated bone volume ($mm^3$ 수식 이미지) of 1% TC-loaded SFM, SFM, and control were $36.56{\pm}8.50$ 수식 이미지, $25.86{\pm}8.17$ 수식 이미지, and $19.09{\pm}5.07$ 수식 이미지 at 8 weeks postoperatively, respectively (P<0.05).
Conclusion: The 1% TC-loaded SFM showed more bone regeneration than the SFM and the uncovered control, in guided bone regeneration.
|
|
|
KEYWORD
|
|
|
Tetracycline, Silk fibroin, Guided bone regeneration
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|